| 名稱 | ALK p.F1174L Reference Standard |
| 型號(hào) | CBP10225 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | ALK p.F1174L Reference Standard |
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10225ALK p.F1174L Reference Standard
- 詳細(xì)內(nèi)容
CBP10225 | |
| Format | Genomic DNA |
| Description | ALK F1174L lies within the protein kinase domain of the Alk protein (UniProt.org). F1174L confers a gain of function to the Alk protein as indicated by transformation activity and increased cell proliferation in culture (PMID: 18923525, PMID: 29533785, PMID: 29907598), and has been demonstrated to occur as a secondary resistance mutation in the context of ALK fusions (PMID: 21030459). |
| Technical Data | |
| DNA Change | c.3522C>A |
| AA Change | p.F1174L |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 33.33% |
| Transcript | ENST00000389048 |
| Cosmic ID | COSM28055 |
| Chr position(GRCh37) | chr2:29443695 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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